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KMID : 0363319760010010070
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Journal of Korean Oriental Internal Medicine
1976 Volume.1 No. 1 p.70 ~ p.77
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A STUDY FOR THE EFFECT OF SAM MOOL INJIN EXTRACT ON THE Ccl₄ INDUCED LIVER DAMAGE OF WISTER RAT
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Abstract
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The Sam Mool Injin extract is occasionally used as a kind of remedies for the treatment of hepatic discomfort in herb medicine. The study for the effect on the hepatic parenchymal cells, especially regenerating activity and even its toxicity have. little been done and only a very few pharmacological properties have been reported.
So, an experimental study for the morphologic changes in the acute carbon tetrachloride poisoning of wister rat by administration of its extract has been performed.
Male Wister rat weighing around 200gm were used in this experiment. Results were as follows;
I ) In the Cc14 0. 3c. c 7day group, there is noted considerable increase of regen-erating activity in the experimental group compared with non-extract treated group, in half of them.
2) Remaining all of the experimental group do not show significant difference of regenerating activity compared with control group.
3) In the group treated with Sam Mool Injin extract alone, there was noted some considerable increase of nonspecific leukocytic infiltrations compared with saline control group.
This can be considered as a possibility of hepatic tissue reaction on the Sam Mool Injin extract.
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